Inflammatory response to trauma

Inflammatory Response to Burn Trauma: Nicotine Attenuates Proinflammatory Cytokine Levels

OBJECTIVE The immune response to an inflammatory stimulus is balanced and orchestrated by stimulatory and inhibitory factors. After a thermal trauma, this balance is disturbed and an excessive immune reaction with increased production and release of proinflammatory cytokines results. The nicotine-stimulated anti-inflammatory reflex offsets this. The goal of this study was to verify that transde...

Modulation of Inflammatory Response in Surgical Trauma

Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. The thesis aims to describe the body's inflammatory response during major surgery and the extent to which the answer depends on different methods of blood salvage, anesthesia and surgical technique. Method: Twenty-four pat...

Local versus systemic inflammatory response in shock, trauma and sepsis

Pathophysiology of the systemic inflammatory response after major accidental trauma

BACKGROUND The purpose of the present study was to describe the pathophysiology of the systemic inflammatory response after major trauma and the timing of final reconstructive surgery. METHODS An unsystematic review of the medical literature was performed and articles pertaining to the inflammatory response to trauma were obtained. The literature selected was based on the preference and clini...

The Biochemical Response to Trauma

The changes that occur in the concentration of chemical constituents of plasma and damaged tissue following trauma have been investigated for many years. The biochemical changes following burns (1) and hemorrhage (2), the protein changes under similar types of injury (3), and those in the nitrogenous compounds (4) have been studied in some detail, and Engel (5) has recently reviewed several asp...